Described is a Statistical Engineering business management approach where a unique predictive organizational performance measurement and improvement system can be used to orchestrate efforts for addressing today’s challenges. This system provides an integrated methodology where organizations can “look out their car’s windshield” and, if they don’t like what they see, can make adjustments through targeted Lean Six Sigma and other improvement efforts that positively impact the business as a whole. This session will illustrate the application of these Statistical Engineering methods to a hospital showing how not only mean operational/financial responses can be improved and demonstrated, but how a reduction in the metric’s variability can occur as well.