This presentation describes a measurement and improvement strategy that addresses all these issues and can take organizations to their next level. To compete in today’s marketplace, employees must be aligned and working on what is valued by their customers. Organizations need to have a system that replaces firefighting activities with fire prevention. In today’s economy, business’s Existence (and Excellence) depends on More Customers and Cash; i.e., E=MC2. Organizations need to create an enterprise where everyone’s activity is aligned and driven toward effectively achieving MC2. Measurements drive activities; however, many measurements do not drive the most effective activity. Described is a statistically-based measurement methodology that tracks an organization as an enterprise of interconnecting processes of supplier-customer relationships, which pulls for the creation of Lean Six Sigma improvement projects that are in direct alignment with business needs.